Historically underrepresented populations experience a disproportionate burden of age-related cognitive disorders compared to non-White populations. As a salient resource for coping in Black communities, spirituality may be associated with better brain health, yet research is limited, especially in this population. This study aims to examine: 1) associations between spirituality and cognition, 2) identify possible differences across racial groups and, 3) explore the role of spirituality as a moderator between AD blood biomarkers and cognition.