This study is designed to investigate the effects of nutrition and disease on child growth and adult health. Among the principal outcome variables to be investigated are insulin resistance and diabetes. The main input variables are birth weight, breastfeeding, and childhood nutrition and disease. We will use multilevel, multivariate models to investigate these relations. The rich longitudinal data available from the INCAP project in El Progreso, Guatemala will enable us to estimate directly the impact of childhood disease and nutrition on adult outcomes.