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Notice NOT-OD-25-079 from the NIH Guide for Grants and Contracts

NIH study finds number of steps taken daily may be more important for cancer risk than the intensity of activity.

We have posted an Implementation of New Initiatives and Policies page on the public NIH Grants & Funding Website to pull together the latest information on recent and upcoming changes that impact applications and grants administration.

NIH has been hard at work over the last two years developing guidance and training to help prepare the community for the implementation of the simplified review framework that went into effect on January 25, 2025 and applies to applications for most research project grants. The framework is a new way of reviewing the same research strategies you’ve always developed, which means neither the components nor the structure of your application are expected to change. 

Researchers found that a protein made by tiny creatures called tardigrades can protect mouse and human cells from radiation damage.

Scientists developed a compound that appeared to relieve pain in mice without adverse side effects.

Researchers found evidence that the human immune system can produce antibodies to neutralize diverse norovirus strains and types.

Treatment shows potential to slow the progression of human degenerative eye diseases, including retinitis pigmentosa.

NIH-funded study uses cutting-edge imaging techniques to reconstruct features underlying learning and memory in the mouse brain.

NIH recently launched several enhancements to allow the public to more easily and quickly find funding information for various NIH research areas. The new look and feel of the NIH Research, Condition, and Disease Categorization (RCDC) Categorical Spending webpage adds to NIH’s long-standing efforts to enhance transparency and accountability into NIH funding decisions and the research areas NIH supports.

Preclinical study in rodents suggests that uric acid is ready for human clinical testing.

NIH-funded study supports use of adenotonsillectomy in this at-risk patient group.

Lassa fever is a viral hemorrhagic disease that can be fatal and that causes permanent hearing loss.

Criteria may help guide treatment of dermatitis.

Do you want to learn more about how applications will be reviewed under the simplified review framework for most research project grants? Whether you’re a peer reviewer awaiting training or a researcher preparing an application, we invite you to review our reviewer guidance page for the simplified review framework.

NIH-sponsored trial data offer further evidence to help inform mpox treatment decisions.

Researchers constructed a map of molecular and cellular changes in marmoset brains that occur in developing lesions like those in multiple sclerosis (MS).

Researchers designed a gene-editing system that replaced up to a quarter of the main type of cell in the mouse liver with edited cells.

Researchers developed an approach that can predict preeclampsia in pregnant women as early as the first trimester by using cell-free DNA in blood samples.

The proposed approach is expected to save more than $65 million annually.