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The Personal Profile module in eRA Commons is where you — as a principal investigator, award recipient, trainee, reviewer or other Commons user — tell NIH and other awarding agencies about yourself. Awarding agencies need to know about you to grant awards, process those awards and more. Here are a few reasons that it is extremely important to keep your Personal Profile updated.  

Funding Opportunity PAR-25-352 from the NIH Guide for Grants and Contracts. Reissue of PAR-20-118. This Notice of Funding Opportunity (NOFO) encourages applications to advance the discovery, preclinical development, and proof of concept (PoC) testing of new, rationally based candidate agents and neurostimulation approaches to treat mental disorders, substance use disorders (SUDs) or alcohol use disorder (AUD), and to develop novel ligands and circuit-engagement devices as tools to further characterize existing or to validate new drug/device targets. Partnerships between academia and industry are strongly encouraged. This NOFO using the U01 mechanism supports a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies Projects seeking support for a research program of multiple projects directed toward a specific major objective, basic theme or program goal, requiring a broadly based, multidisciplinary and often long-term approach should consider the companion U19 FOA.

Notice NOT-RM-25-001 from the NIH Guide for Grants and Contracts

Notice NOT-AG-24-031 from the NIH Guide for Grants and Contracts

Notice NOT-CA-25-021 from the NIH Guide for Grants and Contracts

Notice NOT-HL-25-004 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-DK-26-007 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invites applications for studies of type 1 diabetes etiology and pathogenesis using data and samples from clinical trials and studies. This opportunity is intended to fund investigative teams collaborating to answer important questions about disease mechanisms leading to improved prevention of type 1 diabetes.

Dr. Bertagnolli served as the 17th NIH Director.

NIH has issued agency-specific information regarding its implementation of the U.S. Government Policy for Oversight of Dual Use Research of Concern and Pathogens with Enhanced Pandemic Potential (DURC/PEPP Policy). The policy, which goes into effect May 6, 2025, is a unified federal oversight framework for conducting and managing certain types of federally funded life sciences research on biological agents and toxins.

Notice NOT-OD-25-063 from the NIH Guide for Grants and Contracts

Notice NOT-HL-24-032 from the NIH Guide for Grants and Contracts

Notice NOT-NS-25-009 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-25-313 from the NIH Guide for Grants and Contracts. The purpose of the NCI Pathway to Independence Award (K99/R00) program is to facilitate a timely transition of talented postdoctoral researchers with a research and/or clinical doctorate degree from mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NCI research support during this transition in order to help awardees to launch competitive, independent research careers.

Notice NOT-CA-25-022 from the NIH Guide for Grants and Contracts

Notice NOT-OD-25-064 from the NIH Guide for Grants and Contracts

Researchers uncovered the structural details of how low-density lipoprotein (LDL), or “bad,” cholesterol, interacts with its receptor molecule to enter cells.

A vaccine made by connecting antigens from different flu strains together elicited a more broadly protective immune response than a conventional flu vaccine.

Most deaths avoided from common cancers between 1975 and 2020 could be traced to prevention and screening efforts.

ME/CFS is a complex, serious, and chronic condition that often occurs following an infection.

Early Stage Investigator eligibility is calculated in the eRA Commons system, using information provided by the investigator in their eRA Commons Personal Profile. Learn more about how eligibility is determined on the ESI status page.